Outcomes of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (significant route) and CYP2C9 (slight route). Consequently, inhibitors of these isoenzymes may well lessen sildenafil clearance and inducers of those isoenzymes may raise sildenafil clearance.Moreover, N-desmethyl metabolite AUC and Cmax values appreciabl